Novel Drug Action for HIV / AIDS

The LASER ART developed by the UNMC scientists is a formulation of injectable drugs, he said. The long-lasting medication was developed by making pharmacological changes in the chemical structure of the drug, while at the same time protecting its abilities to contain infection.
The new drug formulation is not an anti-HIV medicine, but rather one that opens storage areas inside cells where drugs can be maintained for a long period of time. This extends the intervals for dosing and allows physicians to administer the drug over an extended period of time.
 
To accomplish this, the scientists merged LASER ART with URMC-099, which alone has no antiviral effect. Co-administration with antiretroviral medicines provides enhanced viral suppression.
The scientists discovered that several innovative strategies -- slow drug dissolution, poor water-solubility and improved bioavailability -- could bring the medication to the sites of active viral growth and accelerate clearance of the virus.
"The Scientist showed that one drug can deliver the other drug to sites inside the cells where the virus grows and at the same time sequester the drug crystals at sites protecting it from degradation". "The drug inside the cell slowly dissolves from the crystal and is released into the blood”.
"This is a new way to extend the actions of drugs”. It is a means to improve drug effectiveness and to allow patients to take drugs without interruption."
The drugs were formulated through UNMC's good laboratory practice (GLP) manufacturing facility.
The next step is to formulate URMC-099 with drug cocktails and investigate whether such a chemical marriage can extend the half lives of many other anti-retroviral and a spectrum of other drugs. Ultimately, they hope to combine URMC-099 with drugs that have been limited for human use due to the frequency and bioavailability of their required dosing to be effective.

Summary : Using a process called LASER ART (long-acting slow effective release antiretroviral therapy), a research team has discovered an unexpected pathway to open cell storage areas for antiviral drugs. The discovery could revolutionize current treatments for HIV/AIDS by extending the actions of disease-combating medicines

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