RECENT DEVELOPMENTS IN DRUG DELIVERY

Innovative and complex ideas in the field of polymer injectable drug delivery systems. For customised products such as new and innovative Injectable Drug Delivery Systems, it needs a wide range of polymer technologies including injection moulding, extrusion and assembly. Starting with a first idea through prototyping, design studies, risk analysis, research and development up to mass serial production under clean room conditions, packaging and sterilisation the complete supply chain is more than just complex. Innovative Injectable Drug Delivery Systems With a share, injectable of about 25% was the number two in the global pharma market in 2010, preceded only by oral medication. Double-digit growth rates, for example, in the areas of biotech products and injectable generics show the importance of this market segment.

Oral administration tops the list of approved pharmaceuticals, with approximately 7,468 total products on the market or approved for marketing. However, when looking at the development pipeline, injectable agents outnumber oral agents, with approximately 3,327 injectable agents in development versus 2,686 oral agents, as a result of the booming biotech industry. Medical advances, such as in biologicals, have revolutionized pharmacotherapy for complex diseases, such as rheumatoid arthritis, Crohn's disease, diabetes, and multiple sclerosis. All other things being equal, subcutaneous is generally the preferred injectable route as it can be easily performed by the patient at home using delivery devices, such as auto -injectors or pen injectors. 

Tailoring the delivery of injectable drugs is mainly dependant on the specifics of two parameters: formulation and device. When injection is a necessity, new delivery technologies can improve the experience in several ways. For example, formulation enhancements can reduce the frequency of administration, reduce the volume needed for each injection, or reduce side effects associated with the formulation, such as immunogenicity. Delivery device improvements, such as a smaller needle or autoinjectors that improve ease of self-injection, can significantly improve the patient experience. Although the pharmaceutical industry makes many attempts to move away from injectable administration, injectable drugs continue to fill the development pipeline. Several companies are making great strides in improving the patient experience of self-injection. 

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