Drug Discovery and Development

At initial stage of Drug  Discovery, based on the single molecule disease target, scientist identifies the high specificity compound which modulates and interacts with the target. The approach used by them was “one target and one drug” approach which is the failure one. Thus, result in the intake of series of specific target drugs which reacts in ineffective way to the isolated target. The new drugs are prepared well than the previous generation to increase the life, strength, reduces the pain and suffering. The development of new drugs makes the pharma industry to take risk in cost and time. The new Drugs are discovered in the basis of cheap (to the people) and more effective. The various phase are there for drug discovery and development, at last the drug enters via New Drug Application (NDA) and then launched into the market only by satisfying FDA rules and regulations. The base for the drugs is synthetic molecules, which is directly, or indirectly a natural product or polyconstituents. In future the contemporary drugs and Ayurveda will have win –win relationship. Contemporary Drug discovery and development (DD) process is becoming longer and expensive. Establishing the right balance between efficacy and safety is the crucial part of DD process.

For more specific treatment, genetic engineering applications have been implemented, where targeted diseased gene is treated in more effective way by combination of pharmacology and genetic engineering.

Developments of new rationally designed targeted therapies:: Several recent phase-I trials of molecularly targeted agents have demonstrated remarkable progress when patients were selected based on their molecular profile and subsequently treated with an agent directed against this specific target. The shift from ‘one size fits all’ to molecularly defined subpopulations has been particularly successful in the treatment of patients.